Genome Diversity Center

at the Institute of Evolution, University of Haifa

(Since August 2000)
Head: Edward N. Trifonov




How the triplet code came about?


This is a completely new development.
The history of the triplet code can be reconstructed in detail from modern sequence data, and expert estimates.

Relevant references:


Trifonov, E. N.,
Early molecular evolution,
Isr. J. Ecol. Evol. 52, 375-387 (2006)

Trifonov, E. N. Theory of early molecular evolution: Predictions and confirmations.
In: Discovering Biomolecular Mechanisms with Computational Biology (Ed. F. Eisenhaber),
Landes Bioscience, Georgetown, pp 107-116 (2006)

Trifonov, E. N. The triplet code from first principles. J Biomolec Str Dyn 22, 1-11 (2004)

Trifonov, E. N., Evolution of the code and the earliest proteins.
Reconstruction from present-day sequences. Biophysics 47, 581-586 (2002)

Trifonov, E. N., Berezovsky, I. N., Molecular evolution from abiotic scratch,
FEBS Letters 527, 1-4 (2002)

Trifonov, E. N., Consensus temporal order of amino acids and evolution of the triplet code.
Gene 261, 139-151 (2000)

Trifonov, E. N., Molecular evolution, over three billion years back.
Biophysics 45, 551-553 (2000) [Biofizika 45, 565-568 (2000)]

Trifonov, E. N., Leap Into Life's Beginnings. Tracking the chronology of amino acids.
Science Spectra 20, 62-71 (2000).
www.gbhap.com/Science_Spectra/

Trifonov, E. N., Glycine clock: Eubacteria first, Archaea next, Protoctista, Fungi, Planta and Animalia at last.
Gene Therapy and Molecular Biology 4, 313-322 (1999).
www.gtmb.org

Trifonov, E. N., Elucidating sequence codes: three codes for evolution.
Annals NY Acad. Sci. 870, 330-338 (1999).
(Title of the volume: Molecular Strategies in Biological Evolution, Ed. L. Caporale).

Trifonov, E. N., Glycine clock: Eubacteria first, Archaea next, Protoctista, Fungi, Planta and Animalia at last.
Gene Therapy and Molecular Biology, Proceedings of the International Conference, Redwood City, April 1999,
Gene Therapy Press, Palo Alto, pp. 275-279

Trifonov, E. N., How basics of protein evolution could help the gene finding.
Proccedings of the First International Conference on Bioinformatics of Genome Regulation and Structure
BGRS'98, Novosibirsk - Altai Mountains, August 24-31, 1998,
ICG, Novosibirsk, 1998, v.2. Bioinformatics of Genome Structure, pp. 266-268

Trifonov, E. N., Bettecken, T., Sequence fossils, triplet expansion, and reconstruction of earliest codons.
Gene 205, 1-6 (1997)

Lagunez-Otero, J., Trifonov, E. N.,
mRNA periodical infrastructure complementary to the proof-reading site in the ribosome.
J. Biomolec. Str. and Dynamics 10, 455-464 (1992)