Genome Diversity Center

at the Institute of Evolution, University of Haifa

(Since August 2000)
Head: Edward N. Trifonov

Is fast adaptation there, in the sequences?

The highly diverse phenotypical features could be matched only by highly diverse component of the genome - tandemly repeating sequences.
The copy numbers of the repeats seem to act as tuners of the gene expression and higher phenotypical levels.

Relevant references:

Trifonov, E. N., The tuning function of the tandemly repeating sequences: molecular device for fast adaptation.
In: Evolutionary Theory and Processes: Modern Horizons, Wasser, S. P. (Ed.),
Kluwer Academic Publishers, pp 115-138 (2004)

Trifonov, E. N., Tandem repeats.
In: "Encyclopedia of Molecular Biology", T. E. Creighton, Ed., John Wiley & Sons, Inc.,
New York, 1999, p. 2513-2514

Trifonov, E. N., Elucidating sequence codes: three codes for evolution.
Annals NY Acad. Sci. 870, 330-338 (1999).
(Title of the volume: Molecular Strategies in Biological Evolution, Ed. L. Caporale).

Trifonov, E. N., Making sense of the human genome.
In: "Structure and Methods, vol. 1, Human Genome Initiative and DNA Recombination",
(Eds. R. H. Sarma and M. H. Sarma), Adenine Press, New York, 1990, pp. 69-77

Trifonov, E. N., The multiple codes of nucleotide sequences.
Bull. Math. Biol. 51, 417-432 (1989)