Genome Diversity Center

at the Institute of Evolution, University of Haifa

(Since August 2000)
Head: Edward N. Trifonov

May the sequences be treated linguistically?

Although the sequences principally differ from human texts by the multiplicity and overlapping of the codes, various types of linguistic description of the sequences are a good lead to biologically relevant observations.

Relevant references:

Kirzhner V, Nevo E, Korol A, Bolshoy A.
A large-scale comparison of genomic sequences: one promising approach.
Acta Biotheor. 51(2):73-89. (2003)

Guimaraes, R. C., Trifonov, E. N., Lagunez-Otero, J.,
Taxonomy of 5S ribosomal RNA by the linguistic technique: probing with mitochondrial and mammalian sequences.
J. Molec. Evol. 45, 271-277 (1997)

Trifonov, E. N., DNA as a language.
In "The Second International Conference on Bioinformatics, Supercomputing and Complex Genome Analysis"
(Eds. H. A. Lim, J. W. Fickett, C. R. Cantor and R. J. Robbins), World Scientific, Singapore, 1993, pp. 103-110

Pietrokovski, S., Trifonov, E. N.,
Imported sequences in yeast mitochondrial genome identified by nucleotide linguistics.
Gene 122, 129-137 (1992)

Trifonov, E. N., Genetic sequences as a language.
Rev. Brasileira de Genetica 15, Suppl. 1, 180-186 (1992)

Pietrokovski, S., Hirshon, J., Trifonov, E. N.,
Linguistic measure of taxonomic and functional relatedness of nucleotide sequences.
J. Biomolec. Str. and Dynamics 7, 1251-1268 (1990)

Trifonov, E. N., Nucleotide sequences as a language: morphological classes of words.
In: "Classification and Related Methods of Data Analysis", (Ed. H. H. Bock),
Elsevier Science Publ. B. V. (North Holland), 1988, pp. 57-64

Beckmann, J. S., Brendel, V., Trifonov, E. N.,
Intervening sequences exhibit distinct vocabulary.
J. Biomolec. Str. and Dynamics 4, 391-400 (1986)

Brendel, V., Beckmann, J. S., Trifonov, E. N.,
Linguistics of nucleotide sequences: morphology and comparison of vocabularies.
J. Biomolec. Str. and Dynamics 4, 11-21 (1986)

Trifonov, E. N., Brendel, V., Gnomic - a dictionary of genetic codes (BOOK).
Balaban Publishers, Rehovot-Philadelphia, 1986. Reprint: Verlag Chemie, 1987