Genome Diversity Center

at the Institute of Evolution, University of Haifa

(Since August 2000)
Head: Edward N. Trifonov

Why the "non-coding" sequences?

The non-coding sequences are responsible for genome evolution (by tranposition events),
fast adaptation (by tunable copy numbers of simple repeats),
chromatin architecture, and many other things yet to explore.

Relevant references:

King, D. G., Trifonov, E. N., Kashi, Y.,
Tuning knobs in the genome: evolution of simple sequence repeats by indirect selection.
In "The Implicit Genome" (Ed. L. H. Caporale), Oxford University Press, New York, pp 77-90 (2006)

Trifonov, E. N., The tuning function of the tandemly repeating sequences: molecular device for fast adaptation.
In: Evolutionary Theory and Processes: Modern Horizons, Wasser, S. P. (Ed.),
Kluwer Academic Publishers, pp 115-138 (2004)

Jurka, J., Klonowski, P., Trifonov, E. N., Mammalian retroposons integrate at sequence-dependent DNA kinks.
J. Biomolec. Str. Dyn. 15, 717-721 (1998)

Trifonov, E. N., Gene splicing: spatial separation of overlapping messages.
Computers Chem. 17, 27-31 (1993)

Trifonov, E. N., DNA as chromatin organizer.
In: "Theoretical Biochemistry and Molecular Biophysics, v. 1: DNA" (Eds. D. L. Beveridge and R. Lavery),
Adenine. Press, New York, 1991, pp. 377-388

Trifonov, E. N., Structure of DNA in chromatin. In: "International Cell Biology 1980-1981" (Ed. H. Schweiger),
Springer-Verlag, Berlin, 1981, pp. 128-138