Genome Diversity Center
at the Institute of Evolution, University of Haifa
(Since August 2000)
Head: Edward N. Trifonov
Why the "non-coding" sequences?
The non-coding sequences are responsible for genome evolution (by tranposition events),
fast adaptation (by tunable copy numbers of simple repeats),
chromatin architecture, and many other things yet to explore.
King, D. G., Trifonov, E. N., Kashi, Y.,
Tuning knobs in the genome: evolution of simple sequence repeats by indirect selection.
In "The Implicit Genome" (Ed. L. H. Caporale), Oxford University Press, New York, pp 77-90 (2006)
Trifonov, E. N., The tuning function of the tandemly repeating sequences: molecular device for fast adaptation.
In: Evolutionary Theory and Processes: Modern Horizons, Wasser, S. P. (Ed.),
Kluwer Academic Publishers, pp 115-138 (2004)
Jurka, J., Klonowski, P., Trifonov, E. N., Mammalian retroposons integrate at sequence-dependent DNA kinks.
J. Biomolec. Str. Dyn. 15, 717-721 (1998)
Trifonov, E. N., Gene splicing: spatial separation of overlapping messages.
Computers Chem. 17, 27-31 (1993)
Trifonov, E. N., DNA as chromatin organizer.
In: "Theoretical Biochemistry and Molecular Biophysics, v. 1: DNA" (Eds. D. L. Beveridge and R. Lavery),
Adenine. Press, New York, 1991, pp. 377-388
Trifonov, E. N., Structure of DNA in chromatin. In: "International Cell Biology 1980-1981" (Ed. H. Schweiger),
Springer-Verlag, Berlin, 1981, pp. 128-138